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020 _a9783031381768
_9978-3-031-38176-8
050 4 _aR850.A1-854
050 4 _aQH315-320
072 7 _aMBGR
_2bicssc
072 7 _aMED062000
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072 7 _aMBGR
_2thema
082 0 4 _a610.72
_223
245 1 0 _aTargeting Lysine Demethylases in Cancer and Other Human Diseases
_h[electronic resource] /
_cedited by Qin Yan.
250 _a1st ed. 2023.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2023.
300 _aVII, 184 p. 35 illus., 28 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x2214-8019 ;
_v1433
500 _aAcceso multiusuario
505 0 _aChapter 1. Lysine demethylation in pathogenesis -- Chapter 2. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases -- Chapter 3. KDM2 demethylases as drug targets -- Chapter 4. Role of histone demethylase KDM3 (JMJD1) in transcriptional regulation and cancer progression -- Chapter 5. KDM4 demethylases as drug targets -- Chapter 6. KDM5 lysine demethylases in pathogenesis, from basic science discovery to the clinic -- Chapter 7. Context-dependent functions of lysine demethylases in physiology and disease -- Chapter 8. KDM7 demethylases as drug targets.
520 _aThis book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications. The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic.
541 _fUABC ;
_cPerpetuidad
650 0 _aMedicine
_xResearch.
650 0 _aBiology
_xResearch.
650 1 4 _aBiomedical Research.
700 1 _aYan, Qin.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031381751
776 0 8 _iPrinted edition:
_z9783031381775
776 0 8 _iPrinted edition:
_z9783031381782
830 0 _aAdvances in Experimental Medicine and Biology,
_x2214-8019 ;
_v1433
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-38176-8
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
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