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001 | 978-981-99-7471-9 | ||
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_aHematopoietic Stem Cells _h[electronic resource] : _bKeystone of Tissue Development and Regenerative Medicine / _cedited by Meng Zhao, Pengxu Qian. |
250 | _a1st ed. 2023. | ||
264 | 1 |
_aSingapore : _bSpringer Nature Singapore : _bImprint: Springer, _c2023. |
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300 |
_aXV, 210 p. 1 illus. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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_atext file _bPDF _2rda |
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490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x2214-8019 ; _v1442 |
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500 | _aAcceso multiusuario | ||
505 | 0 | _aChapter 1. Hematopoietic Stem Cell Development in Mammalian Embryos -- Chapter 2. Hematopoietic Stem Cells and Their Bone Marrow Niches -- Chapter 3. Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis -- Chapter 4. Metabolism in Hematopoiesis and Its Malignancy -- Chapter 5. The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases -- Chapter 6. Ex vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells -- Chapter 7. N6-methyladenosine RNA Modification in Normal and Malignant Hematopoiesis -- Chapter 8. Immune System Influence on Hematopoietic Stem Cells and Leukemia Development -- Chapter 9. Learning from Zebrafish Hematopoiesis -- Chapter 10. Multi-lineage Differentiation from Hematopoietic Stem Cells -- Chapter 11. Gene Editing in Hematopoietic Stem Cells -- Chapter 12. Aging, Causes and Rejuvenation of Hematopoietic Stem Cells. | |
520 | _aThis book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic. | ||
541 |
_fUABC ; _cPerpetuidad |
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650 | 0 |
_aMedicine _xResearch. |
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650 | 0 |
_aBiology _xResearch. |
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650 | 0 | _aStem cells. | |
650 | 0 | _aDevelopmental biology. | |
650 | 1 | 4 | _aBiomedical Research. |
650 | 2 | 4 | _aStem Cell Biology. |
650 | 2 | 4 | _aDevelopmental Biology and Stem Cells. |
700 | 1 |
_aZhao, Meng. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
|
700 | 1 |
_aQian, Pengxu. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
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710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer Nature eBook | |
776 | 0 | 8 |
_iPrinted edition: _z9789819974702 |
776 | 0 | 8 |
_iPrinted edition: _z9789819974726 |
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_iPrinted edition: _z9789819974733 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x2214-8019 ; _v1442 |
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856 | 4 | 0 |
_zLibro electrónico _uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-981-99-7471-9 |
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