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245 1 0 _aDrugs from Nature: Targets, Assay Systems and Leads
_h[electronic resource] /
_cedited by Madhathilkovilakathu Haridas, Sabu Abdulhameed, Dileep Francis, Swaroop S Kumar.
250 _a1st ed. 2024.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2024.
300 _aXIV, 568 p. 1 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
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505 0 _aChapter 1. History of therapeutic discovery from natural sources -- Chapter 2. The process of drug development from natural sources -- Chapter 3. Ayurveda-inspired reverse pharmacology in drug discovery -- Chapter 4. Contemporary approaches in drug target identification and validation -- Chapter 5. Assay systems for identification of drug leads: contemporary approaches -- Chapter 6. Computational biology in lead identification and drug development -- Chapter 7. Physiology of inflammatory responses to external and autoimmune agents of diseases -- Chapter 8. Non-steroidal anti-inflammatory drug leads from natural sources -- Chapter 9. Mechanisms of side effects of non-steroidal anti-inflammatory drugs -- Chapter 10. Therapeutic targets in cancer -- Chapter 11. Anti-neoplastic drug leads from plants and microbes -- Chapter 12. Anti-fungal, anti-bacterial, and anti-parasitic therapeutics from natural sources -- Chapter 13. Anti-viral therapeutics from plants and microbes -- Chapter 14. Cardiovascular therapeutics from natural sources -- Chapter 15. Antidiabetics and antilipemics from nature -- Chapter 16. Therapeutic targets and drug leads for reproductive health -- Chapter 17. Drug leadsfor neuro-muscular disorders from natural sources.
520 _aThis book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery. Focusing on the drug targets blocked/altered by natural/nature-inspired molecules, it covers how potential drug leads are screened and identified using appropriate assay systems, and the current status of drugs identified using such approaches. State-of-the-art approaches in target identification, assay development, and lead identification have also been discussed in detail. Other topics included are targets and leads in inflammation, cancer, reproductive medicine, cardiovascular and neuromuscular ailments, and infectious diseases as well as the challenges in translating drug leads into clinically viable drugs. This volume serves as a handbook for researchers in phytochemistry and drug discovery, and as a reference for researchers and students of applied biology.
541 _fUABC ;
_cPerpetuidad
650 0 _aPharmacology.
650 0 _aBiotechnology.
650 0 _aMedicine
_xResearch.
650 0 _aBiology
_xResearch.
650 1 4 _aPharmacology.
650 2 4 _aBiotechnology.
650 2 4 _aBiomedical Research.
700 1 _aHaridas, Madhathilkovilakathu.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aAbdulhameed, Sabu.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aFrancis, Dileep.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aKumar, Swaroop S.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789819991822
776 0 8 _iPrinted edition:
_z9789819991846
776 0 8 _iPrinted edition:
_z9789819991853
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-981-99-9183-9
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