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020 _a9783031552878
_9978-3-031-55287-8
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072 7 _aMFG
_2bicssc
072 7 _aSCI036000
_2bisacsh
072 7 _aMFG
_2thema
082 0 4 _a612
_223
100 1 _aChen, Chang-Hwei.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aActivation and Detoxification Enzymes
_h[electronic resource] :
_bFunctions and Implications /
_cby Chang-Hwei Chen.
250 _a2nd ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aXXI, 251 p. 50 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aOverview -- Foreign Compounds: Foods, Drugs, Chemicals and Life Styles -- Transport and Excretion of Foreign Compounds -- Metabolic Conversion of Foreign Compounds -- Phase I Activation Enzymes -- Phase II Detoxification Enzymes -- Catalytic Reactions of Activation Enzymes -- Catalytic Reactions of Detoxification Enzymes -- Reactive Intermediates and their Interactions -- Metabolite - Associated Cell Toxicities -- Oxidative Stress and Electrophilic Stress -- Metabolic Enzymes: Polymorphism and Species Differences -- Defense Against Oxidative Stress: Nrf2-ARE Pathway -- Inducibility of Metabolic Enzymes -- Inducers of Metabolic Enzymes -- Diversified Classes of Enzyme Modulators -- Metabolite - Mediated Disease Conditions -- Metabolic Enzyme Induction for Health Benefits -- Diet Effects on Metabolic Enzymes.
520 _aThis book discusses the many advances in the understanding of the functions and implications of activation and detoxification enzymes. This organized, concise overview will meet the needs of those who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology, and chemistry. The book will also be valuable to advanced researchers. The book discusses subjects associated with foreign-compound-metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, activation and detoxification enzymes, metabolic enzyme catalytic properties, reactive metabolic intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary-related enzyme modulators, and structural characteristics of enzyme inducers. This new edition is updated throughout and features completely new chapters on Oxidative and Electrophilic Stresses, Metabolite- Mediated Disease Conditions, and Defense Mechanism: Nrf2-ARE Pathway. .
541 _fUABC ;
_cPerpetuidad
650 0 _aHuman physiology.
650 0 _aEnzymology.
650 0 _aPharmacology.
650 0 _aNutrition   .
650 0 _aBioinformatics.
650 1 4 _aHuman Physiology.
650 2 4 _aEnzymology.
650 2 4 _aPharmacology.
650 2 4 _aNutrition.
650 2 4 _aComputational and Systems Biology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031552861
776 0 8 _iPrinted edition:
_z9783031552885
776 0 8 _iPrinted edition:
_z9783031552892
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-55287-8
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c274764
_d274763