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082 0 4 _a571.978
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082 0 4 _a616.994
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245 1 0 _aDrug Resistance in Cancer: Mechanisms and Strategies
_h[electronic resource] /
_cedited by Sameer Ullah Khan, Fayaz Malik.
250 _a1st ed. 2024.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2024.
300 _aXXIX, 372 p. 58 illus., 56 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _a1. Introduction to Drug Resistance in Cancer -- 2. Mechanisms of Cancer Resistance to Various Therapies -- 3. Role of cancer Stem Cells in Drug Resistance -- 4. Immune cells - Critical players in Drug Resistance -- 5. Tumor Microenvironment: Multiway Role in Drug Resistance -- 6. Cancer Drug Resistance and Metabolic Reprogramming -- 7. Epigenetic alterations as an adaptive response to chemotherapy -- 8. Autophagy plays a dual role in drug resistance -- 9. Intracellular compartments and drug resistance -- 10. Gut microbes: Role in cancer and cancer drug resistance -- 11. Novel strategies for overcoming drug resistance -- 12. Future directions and challenges in overcoming drug resistance in cancer.
520 _aThis book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing Combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.
541 _fUABC ;
_cPerpetuidad
650 0 _aCancer.
650 0 _aCancer
_xTreatment.
650 1 4 _aCancer Biology.
650 2 4 _aCancer Microenvironment.
650 2 4 _aCancer Therapy.
700 1 _aKhan, Sameer Ullah.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMalik, Fayaz.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789819716654
776 0 8 _iPrinted edition:
_z9789819716678
776 0 8 _iPrinted edition:
_z9789819716685
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-981-97-1666-1
912 _aZDB-2-SBL
912 _aZDB-2-SXB
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