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082 0 4 _a571.999
_223
100 1 _aTarique, Mohammed.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aDrug Targets for Plasmodium Falciparum: Historic to Future Perspectives
_h[electronic resource] /
_cby Mohammed Tarique.
250 _a1st ed. 2024.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2024.
300 _aXIII, 199 p. 56 illus., 48 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aChapter 1. Introduction: An overview of Malaria and Plasmodium -- Chapter 2. Pathogenesis of Plasmodium falciparum -- Chapter 3. Antimalarial Drugs and drug resistance -- Chapter 4. Metabolic pathways of Enzymes: Therapeutic targets and prospects for Innovative antimalarial drugs -- Chapter 5. Targeting apicoplasts in Plasmodium falciparum, origin and pathways -- Chapter 6. Proteases and protein kinases as potential drug target -- Chapter 7. Plasmodium falciparum: Transporter and Drug Target -- Chapter 8. Enzymes of isoprenoid biosynthesis and control of malarial parasite plasmodium falciparum -- Chapter 9.Ubiquitin-Proteasome system as a potential drug target for Malaria -- Chapter 10.Food Vacuole as a Drug Target.
520 _aThis book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it. It discusses the challenges posed by the disease, especially in economically developing regions, and delves into the biology and pathophysiology of the Plasmodium species, including their genetic flexibility and resistance to treatments. Special attention is given to P. falciparum, the most dangerous of these parasites, detailing its complex life cycle, interaction with human hosts, and the severe clinical manifestations it can induce. The book further explores the global health concern of antimalarial drug resistance, highlighting the WHO's efforts in combating the disease and the necessity for novel treatments. Innovative research directions, such as targeting the unique organelles of Plasmodium like the apicoplast and employing proteasome inhibitors, are thoroughly examined as potential strategies in the development of new antimalarial drugs. Additionally, it addresses the critical role of the hemoglobin digestion process in the parasite's lifecycle, presenting it as a promising target for therapeutic intervention. This work is an essential resource for researchers, clinicians, and policymakers involved in malaria control and drug development, providing insights into the current challenges and future directions in the fight against this endemic disease.
541 _fUABC ;
_cPerpetuidad
650 0 _aParasitology.
650 0 _aProteins.
650 0 _aDiseases
_xCauses and theories of causation.
650 0 _aPharmacology.
650 1 4 _aParasitology.
650 2 4 _aProteins.
650 2 4 _aPathogenesis.
650 2 4 _aPharmacology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811944833
776 0 8 _iPrinted edition:
_z9789811944857
776 0 8 _iPrinted edition:
_z9789811944864
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-981-19-4484-0
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