000 05840nam a22006135i 4500
001 978-3-031-62731-6
003 DE-He213
005 20250516160105.0
007 cr nn 008mamaa
008 240717s2024 sz | s |||| 0|eng d
020 _a9783031627316
_9978-3-031-62731-6
050 4 _aQH450.2
072 7 _aPSD
_2bicssc
072 7 _aSCI029000
_2bisacsh
072 7 _aPSD
_2thema
082 0 4 _a572.8845
_223
245 1 0 _aTranscription factors in blood cell development
_h[electronic resource] /
_cedited by Tilman Borggrefe, Benedetto Daniele Giaimo.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aXLIV, 430 p. 79 illus., 73 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x2214-8019 ;
_v1459
505 0 _aPart 1 - Stem/Progenitor Cells -- Chapter 1. MYB - A Key Transcription Factor in the Hematopoietic System Subject to many Levels of Control - Roza Berhanu Lemma, Bettina Maria Fuglerud, Jon Frampton & Odd Stokke Gabrielsen -- Part 2 - T-Cells -- Chapter 2. Ikaros Family Transcription Factors in Lymphocyte Differentiation and Function - Philippe Kastner & Susan Chan -- Chapter 3. The Role of the Transcriptional Co-Activator BOB.1/OBF.1 in Adaptive Immunity - Annika C. Betzler & Cornelia Brunner -- Chapter 4. Key Functions of the Transcription Factor BCL6 during T-Cell Differentiation - Chara Konstantakopoulou & Mihalis Verykokakis -- Part 3 - B-Cells -- Chapter 5. The Function of E2A in B-Cell Development - Masaki Miyazaki & Kazuko Miyazaki -- Chapter 6. Hypoxia and the Hypoxia-Inducible Factors in Lymphocyte Differentiation and Function - Mark Boothby & Sung Hoon Cho -- Chapter 7. Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease - Mikael Sigvardsson -- Part 4 - Myeloid Cells -- Chapter 8. Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function - Marc Pfefferlé & Florence Vallelian -- Part 5 - Erythroid Cells -- Chapter 9. Trancriptional Repressor BCL11A In Erythroid Cells - Ge Zheng & Stuart H. Orkin -- Chapter 10. Erythroid Krüppel-like Factor / KLF1: a Surprisingly Versatile Regulator of Erythroid Differentiation - James J Bieker & Sjaak Philipsen -- Chapter 11. Transcription Factor TAL1 in Erythropoiesis - Johannes Fechner & Jörn Lausen -- Part 6 - Megakaryocytes -- Chapter 12. GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development - Kaoru Takasaki & Stella T. Chou -- Part 7 - Leukemia/Lymphoma -- Chapter 13. The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and other Hematopoietic Cancers - Alexander C. Monovich, Aishwarya Gurumurthy & Russell J.H. Ryan -- Chapter 14. Function of PML-RARA in Acute Promyelocytic Leukemia - Ugo Testa & Elvira Pelosi -- Cha[ter 15. MYB as a Critical Transcription Factor and Potential Therapeutic Target in AML - Mary Louise Clarke, Odd Stokke Gabrielsen & Jon Frampton -- Chapter 16. ETS1 Function in Leukemia and Lymphoma - Rebecca A. Luchtel -- Chapter 17. The Molecular and Biological Function of MEF2D in Leukemia - Pengcheng Zhang & Rui Lu -- Chapter 18. HOXA9 Regulome and Pharmacological Interventions in Leukemia - Sajesan Aryal & Rui Lu.
520 _aThis book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts. New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis. This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors.
541 _fUABC ;
_cPerpetuidad
650 0 _aGenetic transcription.
650 0 _aCytology.
650 0 _aPost-translational modification.
650 0 _aHematopoietic system.
650 0 _aDevelopmental biology.
650 1 4 _aGene Transcription.
650 2 4 _aCell Biology.
650 2 4 _aPost-translational Modifications.
650 2 4 _aHaematopoietic System.
650 2 4 _aDevelopmental Biology and Stem Cells.
700 1 _aBorggrefe, Tilman.
_eeditor.
_0(orcid)0000-0003-4325-5452
_1https://orcid.org/0000-0003-4325-5452
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGiaimo, Benedetto Daniele.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031627309
776 0 8 _iPrinted edition:
_z9783031627323
776 0 8 _iPrinted edition:
_z9783031627330
830 0 _aAdvances in Experimental Medicine and Biology,
_x2214-8019 ;
_v1459
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-62731-6
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
999 _c275706
_d275705