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020 _a9783031659867
_9978-3-031-65986-7
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082 0 4 _a571.96
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082 0 4 _a616.079
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245 1 0 _aAntimicrobial Resistance: Factors to Findings
_h[electronic resource] :
_bOmics and Systems Biology Approaches /
_cedited by Vijay Soni, Ajay Suresh Akhade.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2024.
300 _aXV, 454 p. 43 illus., 42 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aAntimicrobial resistance and factors -- Genomics as a tool to track global AMR -- Meta-transcriptomics to reveal mechanisms of drug action and resistance -- Use of proteomics to study bacterial virulence and AMR -- Metabolomics to understand bacterial and drug metabolism -- Microbiome and AMR: A One Health perspective -- Environmental reservoirs, genomic epidemiology, and mobile genetic elements -- Multiomics approach to control AMR -- Systems biology and AMR -- Host-directed omics approaches to control AMR -- Role of AI and Machine Learning in omics analysis of AMR evolution and surveillance -- Drug discovery and AMR treatments using an omics-based approach -- Future perspectives of omics-systems biology to control AMR: Recommendations and future directions.
520 _aAntimicrobial resistance (AMR) is increasing globally at an incredible rate, and many infectious diseases have already reached an alarming stage of resistance to existing treatments. WHO reports that nearly1.27 million people currently die each year due to resistant infections, and AMR is projected to account for 10 million annual deaths globally by 2050. There is an urgent need for novel approaches to address this issue. Omics technologies are powerful research tools used extensively to study pathogen biology and the activity of microbial agents. These tools, paired with systems biology approaches, can provide novel insights into antimicrobial susceptibility and resistance, and aid in the development of new, more effective measures to combat resistant pathogens. This book provides a comprehensive overview of omics technologies to study pathogen biology, including proteomics, genomics, transcriptomics, metabolomics, and microbiome analysis, and the role of systems biology in developing strategies to combat resistant pathogens. It addresses environmental reservoirs and mobile genetic agents in AMR, host-pathogen interactions and physiology in the development of resistance, drug repurposing and development, and cutting-edge tools such as machine learning, AI for big data analysis, and genomic surveillance. The final section discusses future perspectives on omics-systems biology in AMR, and identifies opportunities for scientific collaboration in the global fight against antimicrobial resistance. This book serves as a comprehensive and accessible resource for researchers in academia and industry focused on immunology, drug development, biotechnology, and systems biology.
541 _fUABC ;
_cPerpetuidad
650 0 _aImmunology.
650 0 _aImmune response.
650 0 _aPathogenic microorganisms.
650 0 _aBioinformatics.
650 0 _aDiseases
_xCauses and theories of causation.
650 0 _aGenomics.
650 1 4 _aImmunology.
650 2 4 _aAntimicrobial Responses.
650 2 4 _aComputational and Systems Biology.
650 2 4 _aPathogenesis.
650 2 4 _aGenomics.
700 1 _aSoni, Vijay.
_eeditor.
_0(orcid)0000-0002-3395-7429
_1https://orcid.org/0000-0002-3395-7429
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aAkhade, Ajay Suresh.
_eeditor.
_0(orcid)0000-0002-0803-2416
_1https://orcid.org/0000-0002-0803-2416
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031659850
776 0 8 _iPrinted edition:
_z9783031659874
776 0 8 _iPrinted edition:
_z9783031659881
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-65986-7
912 _aZDB-2-SBL
912 _aZDB-2-SXB
942 _cLIBRO_ELEC
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