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245 1 0 _aHuman Challenge Studies for Vaccine Development
_h[electronic resource] /
_cedited by Fabio Bagnoli, Giuseppe Del Giudice, Sanjay K. Phogat, Rino Rappuoli.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aVIII, 377 p. 40 illus., 25 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
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490 1 _aCurrent Topics in Microbiology and Immunology,
_x2196-9965 ;
_v445
505 0 _aA brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d'etre, ethnography, selection of volunteers and unit design -- Regulatory aspects of human challenge studies.-Controlled Human Infection challenge studies with RSV -- Human challenge studies with coronaviruses old and new -- Experimental urethral infection with Neisseria gonorrhoeae -- Helicobacter pylori.-Controlled human infection with Bordetella pertussis Human challenge studies for cholera -- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli -- Challenges in developing a controlled human tuberculosis challenge model -- Shigella Controlled Human Infection Models: Current and Future Perspectives -- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella -- Controlled Human Malaria Infection studies in Africa - past, present, and future -- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development.
520 _aThis volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens.
541 _fUABC ;
_cPerpetuidad
650 0 _aImmunology.
650 0 _aMedical microbiology.
650 0 _aMedicine
_xResearch.
650 0 _aBiology
_xResearch.
650 0 _aDiseases
_xCauses and theories of causation.
650 1 4 _aImmunology.
650 2 4 _aMedical Microbiology.
650 2 4 _aTranslational Research.
650 2 4 _aPathogenesis.
700 1 _aBagnoli, Fabio.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aDel Giudice, Giuseppe.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aPhogat, Sanjay K.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRappuoli, Rino.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031631177
776 0 8 _iPrinted edition:
_z9783031631191
776 0 8 _iPrinted edition:
_z9783031631207
830 0 _aCurrent Topics in Microbiology and Immunology,
_x2196-9965 ;
_v445
856 4 0 _zLibro electrónico
_uhttp://libcon.rec.uabc.mx:2048/login?url=https://doi.org/10.1007/978-3-031-63118-4
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