Transporters in drug discovery and development
Lai, Yurong.
Transporters in drug discovery and development detailed concepts and best practice / [recurso electrónico] : Yurong Lai. - Oxford : Elsevier Science, 2013. - 1 online resource (xxiii, 734 p.) : illustrations. - Woodhead Publishing Series in Biomedicine . - Woodhead Publishing series in biomedicine. .
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery.
Includes bibliographical references and index.
Membrane transporters and the diseases corresponding to functional defects -- P-glycoprotein (P-gp/MDR1)/ABCB1 -- Multidrug resistanceassociated protein 2 (MRP2/ABCC2) -- Breast cancer resistance protein (BCRP)/ABCG2 -- The bile salt export pump (BSEP/ABCB11) -- Organic aniontransporting polypeptides (OATPs/SLCOs) -- Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs) -- Drug transporters in drug discovery and development -- 9 Transporter study methodologies.
9781908818287 (electronic bk.) 190881828X (electronic bk.)
Biopharmaceutics.
Drug development.
Drugs--Design.
Biopharmaceutics.
Drug development.
Drugs -- Design.
MEDICAL / Pharmacology
Biopharmaceutics.
Drug development.
Drugs--Design.
Electronic books.
RM301.25
615.19
Transporters in drug discovery and development detailed concepts and best practice / [recurso electrónico] : Yurong Lai. - Oxford : Elsevier Science, 2013. - 1 online resource (xxiii, 734 p.) : illustrations. - Woodhead Publishing Series in Biomedicine . - Woodhead Publishing series in biomedicine. .
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery.
Includes bibliographical references and index.
Membrane transporters and the diseases corresponding to functional defects -- P-glycoprotein (P-gp/MDR1)/ABCB1 -- Multidrug resistanceassociated protein 2 (MRP2/ABCC2) -- Breast cancer resistance protein (BCRP)/ABCG2 -- The bile salt export pump (BSEP/ABCB11) -- Organic aniontransporting polypeptides (OATPs/SLCOs) -- Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs) -- Drug transporters in drug discovery and development -- 9 Transporter study methodologies.
9781908818287 (electronic bk.) 190881828X (electronic bk.)
Biopharmaceutics.
Drug development.
Drugs--Design.
Biopharmaceutics.
Drug development.
Drugs -- Design.
MEDICAL / Pharmacology
Biopharmaceutics.
Drug development.
Drugs--Design.
Electronic books.
RM301.25
615.19
