Transporters in drug discovery and development [recurso electrónico] : detailed concepts and best practice / Yurong Lai.
Tipo de material:
TextoSeries Woodhead Publishing series in biomedicineDetalles de publicación: Oxford : Elsevier Science, 2013Descripción: 1 online resource (xxiii, 734 p.) : illustrationsISBN: 9781908818287 (electronic bk.); 190881828X (electronic bk.)Tema(s): Biopharmaceutics | Drug development | Drugs -- Design | Biopharmaceutics | Drug development | Drugs -- Design | MEDICAL / Pharmacology | Biopharmaceutics | Drug development | Drugs -- DesignGénero/Forma: Electronic books.Formatos físicos adicionales: Print version:: Transporters in Drug Discovery and Development : Detailed Concepts and Best PracticeClasificación CDD: 615.19 Clasificación LoC:RM301.25Recursos en línea: Libro electrónico ScienceDirect
| Tipo de ítem | Biblioteca actual | Colección | Signatura | Copia número | Estado | Fecha de vencimiento | Código de barras |
|---|---|---|---|---|---|---|---|
| Libro Electrónico | Biblioteca Electrónica | Colección de Libros Electrónicos | RM301.25 (Browse shelf(Abre debajo)) | 1 | No para préstamo | 379887-2001 |
Includes bibliographical references and index.
Print version of record.
Membrane transporters and the diseases corresponding to functional defects -- P-glycoprotein (P-gp/MDR1)/ABCB1 -- Multidrug resistanceassociated protein 2 (MRP2/ABCC2) -- Breast cancer resistance protein (BCRP)/ABCG2 -- The bile salt export pump (BSEP/ABCB11) -- Organic aniontransporting polypeptides (OATPs/SLCOs) -- Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs) -- Drug transporters in drug discovery and development -- 9 Transporter study methodologies.
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery.
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